Time to death, airway wall inflammation and remodelling in fatal asthma

Time to death, airway wall inflammation and remodelling in fatal asthma.

Fatal asthma is characterised pathologically by airway wall remodelling, eosinophil and neutrophil infiltration, accumulation of mucus in the airway lumen and smooth muscle shortening. The durations of fatal attacks of asthma show a clear bimodal distribution. Airway smooth muscle contraction and the accumulation of luminal mucus may contribute to death from asthma and relate to time to death. ...

Airway wall remodelling in asthma.

Differences in airway wall remodelling in asthma and EB.

remodelling in asthma and EB We read with interest the study by Park et al published recently in Thorax. We agree that non-asthmatic eosinophilic bronchitis (EB), a condition characterised by eosinophilic inflammation without evidence of variable airflow obstruction, is a powerful disease control group to study the mechanisms involved in the development of airway hyperresponsiveness in asthma. ...

Novel concepts in airway inflammation and remodelling in asthma.

The hallmark pathological features of asthma include airway eosinophilic inflammation and structural changes (remodelling) which are associated with an irreversible loss in lung function that tracks from childhood to adulthood. In parallel with changes in function, pathological abnormalities occur early, during the pre-school years, are established by school age and subsequently remain (even th...

Airway remodelling in asthma and novel therapy.

Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness (BHR) and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. These changes were previously considered as a consequence ...